RESUMO
Objective: to determine the accuracy of anti-tissue transglutaminase IgA [TTG] antibody titer in the diagnosis of celiac disease, taking small intestine histopathology as the gold standard
Study Design: cross-sectional analytical study
Place and Duration of Study: department of Paediatrics, Benazir Bhutto Hospital, Rawalpindi, from February to July 2013
Methodology: sixty patients aged 2 - 13 years, admitted in the Paediatric Department of Benazir Bhutto Hospital, Rawalpindi, having at least 3 features from chronic diarrhea, malnutrition, short stature, anemia, abdominal distension and clubbing, were included. Age, gender, weight and height were recorded. Abdominal distension and clubbing were clinically noted. For hemoglobin, blood complete picture was done. For determination of nutritional status and short stature, standard centile charts were used. TTG titer upper GI endoscopy, duodenal biopsy, and histopathology were done in all cases
Results: there were 60 patients; 32 males, 28 females with mean age of 5.85 +/- 3.36 years. Frequency of CD was 63.33% in study population. Sensitivity of TTG was 86.84%, with 81.82% specificity, 89.19% positive predictive value, and 78.26% negative predictive value for diagnosing CD. TTG titre more than 50 iu/ml had a 100% positive predictive value
Conclusion: TTG is an excellent screening test for the diagnosis of paediatric CD. TTG value > 50 IU/ml has 100% positive predictive value
RESUMO
Objective: to compare the frequencies and clinical features of diarrheal versus non-diarrheal presentation of celiac disease [CD]
Study Design: cross-sectional study
Place and Duration of Study: paediatric Department, Benazir Bhutto Hospital, Rawalpindi, from January to December 2013
Methodology: children with celiac disease, newly diagnosed on the basis of tissue transglutaminasel [TTG] and intestinal histopathology, were included in the study by consecutive non-probability sampling. Patients were divided into diarrheal and non-diarrheal groups on the basis of presence or absence of chronic or recurrent diarrhea. Comparison between two groups was done and a p-value < 0.05 was considered significant
Results: total patients were 54 [26 males, 28 females] with mean age of 6.67 +/-3.35 years. Chronic diarrhea was present in 31 [57.4%] and absent in 23 [42.6%]. Patients in non-diarrheal group were diagnosed at a significantly later age [p=0.038] and had a greater frequency of severe malnutrition [p=0.02]. Short stature, anemia, rickets, clubbing and abdominal distension were equally prevalent. There was no significant difference in TTG value and intestinal histopathology among two groups
Conclusion: children with atypical presentation of CD had significant severe malnutrition and higher age at diagnosis than at diarrheal presentation
RESUMO
Background: Despite efforts to promote widespread vaccination, measles still remains an important cause of morbidity and mortality in children especially in developing countries. The aim of this study was to review the pattern and outcome of measles patients admitted at Benazir Bhutto Hospital [BBH] Rawalpindi during measles epidemic 2013
Study Design: Cross sectional descriptive study
Period: Three months during measles epidemic 2013 [March - May]
Setting: Pediatric department BBH Rawalpind
Materials and Methods: Data regarding demographic profile, clinical presentation, complications and outcome of measles patients was collected and analyzed using SPSS 15
Results: A total of 192 patients of both sexes were included with mean age of 35.48 +/- 32.71 months. Majority of patients[71.4%] were unvaccinated and 88% had history of contact with measles patients. The common complications observed were pneumonia and pneumonia with gastroenteritis and both were found statistically significant in patients with malnutrition and low socioeconomic status
Conclusion: The current study concluded that improving measles immunization and nutritional status in children is essential for reducing morbidity and mortality of measles